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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B6 and Reduced Depression Symptoms

Doses used in studies

mg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 8.1 weeks · IQR 6.2 weeks–10.1 weeks · Range 4.3 weeks–2.8 months — Reported in 2 of 2 studies

2 of 2 papers

High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.
- 2022-07-19
- RCT · n = 307
- Human psychopharmacology 37(6)
- - David T Field
  - Rebekah O Cracknell
  - Jessica R Eastwood
  - Peter Scarfe
  - Claire M Williams
  - Ying Zheng
  - Teresa Tavassoli
- PubMed: 35851507
- DOI: 10.1002/hup.2852
5 Insights on
- Reduced Depression Symptoms
- High evidence
- Large Human Trial
- Adults
Vitamin B6 supplementation... induced a trend towards reduced depression
Effect
Neutral
Effect size
Small
Significant
No
Dose
high-dose
Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial.
- 2022-02-02
- RCT
- Journal of dietary supplements 20(4)
- - Anne C Curtin
  - Carol S Johnston
- PubMed: 35109763
- DOI: 10.1080/19390211.2022.2030843
2 Insights on
- Reduced Depression Symptoms
- High evidence
- Adults
BDI-II scores were reduced 20% by vitamin B6 supplementation in comparison to an 11% rise with placebo ingestion (p = 0.046).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
100 mg daily