Vitamin C and Reduced Morphine Consumption

• Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.

  • 2025-04-09
  • RCT
  • Drug design, development and therapy 19
  • • Guangtao Han
    • Yuna Ye
    • Pengde Kang

  • PubMed: 40231193
  • DOI: 10.2147/dddt.s506262

  4 Insights on

  • Reduced Morphine Consumption

  • High evidence
  • Clinical

  In the vitamin C group, the subcutaneous morphine injection dosage was considerably lower (0-24h 6.1mg ± 2.7mg vs 4.0mg ± 2.9mg, p = 0.000, total use 8.3mg ± 3.1mg vs 6.6mg ± 3.9mg, p = 0.018).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  3g of vitamin C intravenously every day during the perioperative period