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Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.

  • 2025-04-09
  • Drug design, development and therapy 19
    • Guangtao Han
    • Yuna Ye
    • Pengde Kang

Study Design

Type
Randomized Controlled Trial (RCT)
Population
One hundred patients undergoing total hip arthroplasty (THA) at our institution
Methods
prospective, double-blind, placebo-controlled, randomized experiment; vitamin C group received an intravenous injection of 3g of vitamin C every day during the perioperative period; control group received an equivalent daily dose of a placebo
Blinding
Double-blind
Duration
the perioperative period

Purpose

Although the benefits of numerous intravenous vitamin C doses during the perioperative phase on postoperative pain following total hip arthroplasty for whether patients could have pain relief for a longer period of time have not yet been tested, a single dose of vitamin C can assist control pain after the procedure on the first post-operative day.

Methods

One hundred patients undergoing total hip arthroplasty (THA) at our institution were enrolled in this prospective, double-blind, placebo-controlled, randomized experiment. These patients were randomized to either the control group or the vitamin C group. While the control group received an equivalent daily dose of a placebo, the vitamin C group received an intravenous injection of 3g of vitamin C every day during the perioperative period. Ten milliliters of morphine were injected subcutaneously as a rescue analgesic for patients who complained of discomfort following surgery. The amount of morphine used for rescue analgesia and the levels of inflammatory markers were the main outcomes that we evaluated. Additionally, we evaluated postoperative pain and hip joint recovery using the Visual Analog Scale (VAS) as secondary outcomes.

Results

In the vitamin C group, the subcutaneous morphine injection dosage was considerably lower (0-24h 6.1mg ± 2.7mg vs 4.0mg ± 2.9mg, p = 0.000, total use 8.3mg ± 3.1mg vs 6.6mg ± 3.9mg, p = 0.018). During the perioperative term, the vitamin C group experienced better hip motion and lower VAS pain levels at rest and during exercise.

Research Insights

  • Vitamin C→Improved Hip Joint Motion

    During the perioperative term, the vitamin C group experienced better hip motion ...

    Effect
    Beneficial
    Effect size
    Small
    Dose
    3g of vitamin C intravenously every day during the perioperative period
  • Vitamin C→Reduced Inflammatory Markers

    Additionally, we evaluated ... the levels of inflammatory markers were the main outcomes that we evaluated.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    3g of vitamin C intravenously every day during the perioperative period
  • Vitamin C→Reduced Morphine Consumption

    In the vitamin C group, the subcutaneous morphine injection dosage was considerably lower (0-24h 6.1mg ± 2.7mg vs 4.0mg ± 2.9mg, p = 0.000, total use 8.3mg ± 3.1mg vs 6.6mg ± 3.9mg, p = 0.018).

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    3g of vitamin C intravenously every day during the perioperative period
  • Vitamin C→Reduced Pain Intensity

    During the perioperative term, the vitamin C group experienced ... lower VAS pain levels at rest and during exercise.

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    3g of vitamin C intravenously every day during the perioperative period
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