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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin C and Reduced Organ Dysfunction

Doses used in studies

mg/kg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 3 days · IQR 3 days–3 days · Range 3 days–3 days — Reported in 1 of 1 study

Safety in these studies

acute kidney injuryNo significant difference
The incidence of prespecified adverse events (acute kidney injury) was similar in both groups.
from: Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Tr

1 of 1 paper

Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial.
- 2025-07-24
- RCT · n = 262
- Journal of intensive care medicine 41(2)
- - Jhuma Sankar
  - Aravindhan Manoharan
  - Rakesh Lodha
  - H P Sharma
  - S K Kabra
- PubMed: 40708328
- DOI: 10.1177/08850666251362121
3 Insights on
- Reduced Organ Dysfunction
- High evidence
- Large Human Trial
- Clinical
The adjusted mean difference for change in pSOFA score at 72 h between the Vitamin C and placebo groups was -0.51 [95% CI: (-1.76, 0.75)] (p = 0.43)
Effect
Neutral
Effect size
Small
Significant
No
Dose
25 mg/kg every 6 h for 72 h