Vitamin D and Improved Bowel Movement Frequency

• Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.

  • 2025-05-18
  • RCT · n = 35
  • Nutrients 17(10)
  • • Lucrezia Laterza
    • Cesare Cremon
    • Gaetano Coppola
    • Carlo Romano Settanni
    • Rossella Maresca
    • Martina Strazzeri
    • Eleonora Durini
    • Valentina Petito
    • Franco Scaldaferri
    • Giorgio Gargari
    • Diego Mora
    • Elnaz Vojoudi Yazdi
    • Chiara Marangelo
    • Gianluca Ianiro
    • Lorenza Putignani
    • Maria Raffaella Barbaro
    • Giovanni Marasco
    • Giovanni Barbara
    • Antonio Gasbarrini

  • PubMed: 40431448
  • DOI: 10.3390/nu17101708

  4 Insights on

  • Improved Bowel Movement Frequency

  • High evidence
  • Rigorous Journal

  The active group showed a more stable trend toward improvement in stool frequency and consistency at both week 12 and 16, with a significant improvement compared to the baseline and to the placebo group (-23.2, p = 0.0265, and 5.57 vs. -23.2, p = 0.0492, respectively).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes