Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose-response meta-analysis of randomized controlled trials.
- 2026-03-17
- Systematic Review · n = 962
- Frontiers in nutrition 13
- Hsuan-Hsien Liu
- Ting-Hui Liu
- Chia-Yu Liu
- Jheng-Yan Wu
- Chien-Ho Lin
- Chih-Cheng Lai
- PubMed: 41923913
- DOI: 10.3389/fnut.2026.1772451
- High evidence
Vitamin D supplementation demonstrated a significant improvement in depressive symptoms compared to the placebo group (SMD: -0.98; 95% CI - 1.28 to -0.68; p < 0.001).
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- up to 5,000 IU/day