Vitamin D and Improved Insulin Sensitivity

• The Association Between Vitamin D and Polycystic Ovary Syndrome (PCOS) in Women: A Systematic Review.

  • 2026-03-19
  • Systematic Review · n = 1,063
  • Nutrients 18(6)
  • • Batoul Jaafar
    • Nour Chami
    • Mohamad Tlais
    • Maria Matar
    • Nazih Obeid
    • Nadia Taha
    • Karim El Haddad
    • Jessica Abou Chaaya
    • Sami Azar

  • PubMed: 41901143
  • DOI: 10.3390/nu18060968

  3 Insights on

  • Improved Insulin Sensitivity

  • High evidence
  • Rigorous Journal
  • Clinical

  RCTs showed modest and inconsistent improvements in insulin sensitivity, with effects more apparent in some trials enrolling vitamin D-deficient women.

  Effect

  Beneficial

  Effect size

  Small

• Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.

  • 2025-09-18
  • Meta-Analysis
  • Nutrients 17(18)
  • • Alejandro Bruna-Mejías
    • Rocío Valdivia-Arroyo
    • Emelyn Sofia Becerra-Rodríguez
    • Ignacio Clasing-Cárdenas
    • Yesica Tatiana Castaño-Gallego
    • Guinevere Granite
    • Mathias Orellana-Donoso
    • Gustavo Oyanedel-Amaro
    • Pablo Nova-Baeza
    • Gloria Cifuentes-Suazo
    • Alejandra Suazo-Santibañez
    • Juan Sanchis-Gimeno
    • Héctor Gutiérrez Espinoza
    • Juan José Valenzuela-Fuenzalida

  • PubMed: 41010515
  • DOI: 10.3390/nu17182991

  9 Insights on

  • Improved Insulin Sensitivity

  • High evidence
  • Rigorous Journal
  • Clinical

  Vitamin D supplementation was associated with significant improvements across several parameters, including ... HOMA-IR

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.

  • 2026-01-13
  • Review
  • Frontiers in pediatrics 13
  • • Xiao Zhou
    • Yuhe Chen
    • Jianxin Xu
    • Xiaobing Li
    • Yanmei Wu
    • Lidan Xu

  • PubMed: 41608325
  • DOI: 10.3389/fped.2025.1700949

  2 Insights on

  • Improved Insulin Sensitivity

  • Low evidence
  • Clinical

  Meta-analysis of 12 randomised trials (n = 1,538) revealed that vitamin D supplementation improves insulin sensitivity and lowers systolic blood pressure only when baseline 25-hydroxyvitamin D (25(OH)D) is <20 ng/mL and systemic inflammation is modest

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  4,000 IU/day