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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Diarrhea Rate

Doses used in studies

IU/day: 200,000 (median 200,000, IQR 200,000–200,000) — 1 study

Time to effect

Median: 6 weeks · IQR 6 weeks–6 weeks · Range 6 weeks–6 weeks — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Vitamin D3 and deconvoluting a rash.
- 2023-01-24
- RCT · n = 28
- JCI insight 8(2)
- - Madison K Ernst
  - Spencer T Evans
  - Jose-Marc Techner
  - Robert M Rothbaum
  - Luisa F Christensen
  - Ummiye Venus Onay
  - Dauren Biyashev
  - Michael M Demczuk
  - Cuong V Nguyen
  - Kord S Honda
  - Thomas S McCormick
  - Lam C Tsoi
  - Johann E Gudjonsson
  - Kevin D Cooper
  - Kurt Q Lu
- PubMed: 36692020
- DOI: 10.1172/jci.insight.163789
5 Insights on
- Reduced Diarrhea Rate
- High evidence
- Adults
achieved 6 weeks of durable responses
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
200,000 IU
Effect of vitamin D supplementation on motor symptoms in Parkinson's disease: a meta-analysis of randomized controlled trials.
- 2025-06-09
- Systematic Review
- Frontiers in nutrition 12
- - Jing Xu
  - Jia Li
  - Ya-Juan Sun
  - Wei Quan
  - Yi-Dan Qin
  - Jia Song
  - Jia-Jun Chen
- PubMed: 40551732
- DOI: 10.3389/fnut.2025.1500875
4 Insights on
- Reduced Diarrhea Rate
- High evidence
- Clinical
The results indicated that supplemental vitamin D did not reduce the Unified Parkinson's Disease Rating Scale part III score (WMD=-0.56, 95% CI=[-2.34, 1.23])
Effect
Neutral
Effect size
Small
Significant
No