Across 3 studies, all reported small beneficial effects of Vitamin D on reducing inflammation. The evidence is limited but consistently positive, with statistically significant findings in all three studies. No specific dose range or population could be identified due to incomplete reporting.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Effect sizes were small across all studies, suggesting the clinical significance may be modest. Study durations and doses were not consistently reported, limiting the ability to draw practical recommendations.
decreases the ... inflammatory state
High-dose vitamin D₃ has demonstrated benefits in specific populations, including improved bone mineral density, immune homeostasis, glycemic control, and reduced inflammation.
Elevated irisin levels, such as those observed with vitamin D supplementation, could prevent muscle wasting and fat gain in SO by improving insulin sensitivity and reducing inflammation.