Vitamin D and Reduced LDL Cholesterol

Research synthesisLow evidenceSmall effect4 studies · 1 beneficial · 3 neutral · 0 harmful

Across 4 meta-analyses, 1 reported a beneficial small effect of vitamin D supplementation on reducing LDL cholesterol, while 3 found neutral effects. The beneficial effect was observed in patients with diabetes and prediabetes; most studies did not report doses, forms, or durations consistently. Overall, the evidence suggests a predominantly neutral effect with a small magnitude in the one beneficial study.

Studied populations: patients with diabetes and prediabetes

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Doses, forms, and study durations were not consistently reported across studies, limiting dose-specific conclusions.

Generated May 13, 2026

4 of 4 papersPopulation:

Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.
- 2025-11-25
- Meta-Analysis · n = 440
- BMC pediatrics 25(1)
- - Amir Hossein Faghfouri
  - Mahsa Mahmoudinezhad
  - Pedram Pam
  - Sanaz Barazandeh
  - Fatemeh Faramarzi
  - Yousef Mohammadpour
  - Vali Musazadeh
  - Shahsanam Gheibi
- PubMed: 41291584
- DOI: 10.1186/s12887-025-05795-2
9 Insights on
- Reduced LDL Cholesterol
- High evidence
- Children
vitamin D supplementation no significantly improved ... LDL-C
Effect
Neutral
Effect size
Small
Significant
No
Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.
- 2025-09-18
- Meta-Analysis
- Nutrients 17(18)
- - Alejandro Bruna-Mejías
  - Rocío Valdivia-Arroyo
  - Emelyn Sofia Becerra-Rodríguez
  - Ignacio Clasing-Cárdenas
  - Yesica Tatiana Castaño-Gallego
  - Guinevere Granite
  - Mathias Orellana-Donoso
  - Gustavo Oyanedel-Amaro
  - Pablo Nova-Baeza
  - Gloria Cifuentes-Suazo
  - Alejandra Suazo-Santibañez
  - Juan Sanchis-Gimeno
  - Héctor Gutiérrez Espinoza
  - Juan José Valenzuela-Fuenzalida
- PubMed: 41010515
- DOI: 10.3390/nu17182991
13 Insights on
- Reduced LDL Cholesterol
- High evidence
- Rigorous Journal
- Clinical
supplementation significantly reduced ... LDL cholesterol
Effect
Beneficial
Effect size
Small
Significant
Yes
Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic-Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-04
- Meta-Analysis
- The Journal of nutrition 156(4)
- - Bowen Yu
  - Junyan Liu
  - Fangfang Bu
  - Hongli Yan
  - Chen Chen
  - Yanfei Li
  - Yifei Sun
  - Yaqin Wang
  - Junhua Yuan
- PubMed: 41478593
- DOI: 10.1016/j.tjnut.2025.101314
9 Insights on
- Reduced LDL Cholesterol
- High evidence
- Clinical
However, vitamin D supplementation did not show a significant effect on ... or LDL cholesterol (-0.17; 95% CI: -0.41, 0.07).
Effect
Neutral
Effect size
Small
Significant
No
The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials.
- 2024-10
- Meta-Analysis
- Prostaglandins & other lipid mediators 174
- - Zhihong Zhou
  - Jiyuan Liu
  - Hui Zhang
  - Kousalya Prabahar
  - Benjamin Hernández-Wolters
  - Yuanhong Yuan
- PubMed: 39154789
- DOI: 10.1016/j.prostaglandins.2024.106883
12 Insights on
- Reduced LDL Cholesterol
- High evidence
No statistically significant association was observed between vitamin D2 administration and ... LDL-C
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified

Vitamin D and Reduced LDL Cholesterol

Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.

Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.

Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic-Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials.