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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced LDL Cholesterol

Research synthesisLow evidenceSmall effect5 studies · 2 beneficial · 3 neutral · 0 harmful

Across 5 studies, 2 reported beneficial effects and 3 found neutral results, with no evidence of harm. The predominant effect size among beneficial studies was small-to-moderate, and effects were most notable in clinical populations (e.g., women with gestational diabetes). The median study duration was 42 days, but only 1 of 5 studies reported duration, limiting generalizability.

  • Effective dose range: 1000 IU/day
  • Studied populations: women with gestational diabetes mellitus, patients with diabetes and prediabetes

Caveats: Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Evidence base is small (only 5 studies) — conclusions should be considered preliminary. Most studies were meta-analyses with varied populations and forms, and only 1 trial reported a specific dose and duration, limiting dose-response assessment.

Generated Jul 14, 2026
Doses used in studies
  • IU/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study
Time to effect
Median: 6 weeks · IQR 6 weeks–6 weeks · Range 6 weeks–6 weeks — Reported in 1 of 5 studies
5 of 5 papers
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