Vitamin D and Reduced Low-Density Lipoprotein Level

Research synthesisLow evidence3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 studies (all neutral), vitamin D supplementation showed no beneficial effect on reducing low-density lipoprotein (LDL) levels. Effect sizes were consistently small but not statistically significant. The evidence base is small and predominantly drawn from clinical populations (type 2 diabetes, PCOS) and healthy adults, with doses and durations not consistently reported.

Studied populations: clinical populations (type 2 diabetes, PCOS) and healthy adults

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Study durations and doses were not consistently reported, limiting comparability.

Generated Jul 12, 2026

3 of 3 papersPopulation:

The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
- 2024-06-05
- Systematic Review · n = 1,711
- Frontiers in nutrition 11
- - Qingyang Lu
  - Qingyue Liang
  - Yue Xi
- PubMed: 38903615
- DOI: 10.3389/fnut.2024.1419747
4 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Clinical
However, vitamin D supplementation failed to improve low-density lipoprotein (LDL) levels and total cholesterol (TC) levels.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified individually per trial
Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.
- 2025-07-04
- Systematic Review · n = 415
- BMC nutrition 11(1)
- - Caroline Goswami
  - Sherrice Law
  - Hannah Zhang
  - Hannah Park
  - Bhagvat Maheta
  - Katherine Arnott
  - Megan Hsu
  - Kevin Truong
  - Mark Sheffield
  - Zahid Iqbal
  - Chainaronk Limanon
  - David Pai
- PubMed: 40616189
- DOI: 10.1186/s40795-025-01107-0
10 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Adults
Conversely, 11 studies revealed no Vitamin D impact on outcomes including hemoglobin-A1c, lipoproteins, BMI, blood pressures, and respiratory infections.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified
A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome.
- 2026-01-02
- Meta-Analysis
- Medicine 105(1)
- - Baohua Wu
  - Jun Yao
- PubMed: 41496027
- DOI: 10.1097/md.0000000000046892
12 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Clinical
low-density lipoprotein cholesterol (LDL-C) were unaffected.
Effect
Neutral
Effect size
Small
Significant
No

Vitamin D and Reduced Low-Density Lipoprotein Level

The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.

A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome.