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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced Low-Density Lipoprotein Level

Research synthesisLow evidenceSmall effect3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 studies, all reported neutral, small-sized effects of vitamin D supplementation on reducing low-density lipoprotein (LDL) levels. No beneficial or harmful effects were observed. The evidence is drawn primarily from systematic reviews and meta-analyses in clinical populations including type 2 diabetes and polycystic ovarian syndrome, as well as healthy adults. Doses and study durations were not consistently reported, and no statistically significant findings were noted.

  • Studied populations: people with type 2 diabetes, healthy adults, patients with polycystic ovarian syndrome

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Doses and forms were not specified in most studies, limiting the ability to generalize findings.

Generated Jun 11, 2026
3 of 3 papers
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