Vitamin D and Reduced Low-Density Lipoprotein Level

Research synthesisLow evidenceSmall effect4 studies · 1 beneficial · 3 neutral · 0 harmful

Across 4 studies, 1 reported a small beneficial effect of vitamin D on reducing LDL levels, while 3 found no significant effect. The beneficial finding was observed in a systematic review of pediatric patients with metabolic dysfunction-associated steatotic liver disease (MASLD), whereas neutral results were seen in adults with type 2 diabetes, healthy adults, and women with PCOS. The overall evidence is mixed, with a small effect size in the single positive study, but no consistent benefit across populations.

Studied populations: pediatric patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

Caveats: Only one study found a statistically significant benefit, and it was limited to a specific pediatric clinical population; evidence from three other studies in different populations showed no effect. Many of the included studies did not reach statistical significance, suggesting the effect may be small or null. Doses and forms were not consistently reported across studies, limiting dose recommendations.

Generated Jul 14, 2026

4 of 4 papersPopulation:

Efficacy of pharmacotherapies on pediatric patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and network meta-analysis.
- 2025-12-08
- Systematic Review · n = 1,503
- BMC gastroenterology 25(1)
- - Shehab Yaser
  - Hatem Yaser
  - Hazem E Mohammed
  - Mohamed Nasser
  - Mohamed Khalafalla Darwish
  - Mohamed E Haseeb
  - Anas Hussein Heiba
  - Mohamed Mabrouk Ghonaim
  - Heba Aboeldahab
  - Zeyad Bady
- PubMed: 41361375
- DOI: 10.1186/s12876-025-04393-x
7 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Clinical
improving lipid profiles by reducing low-density lipoprotein (LDL)
Effect
Beneficial
Effect size
Small
Significant
Yes
The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
- 2024-06-05
- Systematic Review · n = 1,711
- Frontiers in nutrition 11
- - Qingyang Lu
  - Qingyue Liang
  - Yue Xi
- PubMed: 38903615
- DOI: 10.3389/fnut.2024.1419747
4 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Clinical
However, vitamin D supplementation failed to improve low-density lipoprotein (LDL) levels and total cholesterol (TC) levels.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified individually per trial
Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.
- 2025-07-04
- Systematic Review · n = 415
- BMC nutrition 11(1)
- - Caroline Goswami
  - Sherrice Law
  - Hannah Zhang
  - Hannah Park
  - Bhagvat Maheta
  - Katherine Arnott
  - Megan Hsu
  - Kevin Truong
  - Mark Sheffield
  - Zahid Iqbal
  - Chainaronk Limanon
  - David Pai
- PubMed: 40616189
- DOI: 10.1186/s40795-025-01107-0
10 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Adults
Conversely, 11 studies revealed no Vitamin D impact on outcomes including hemoglobin-A1c, lipoproteins, BMI, blood pressures, and respiratory infections.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified
A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome.
- 2026-01-02
- Meta-Analysis
- Medicine 105(1)
- - Baohua Wu
  - Jun Yao
- PubMed: 41496027
- DOI: 10.1097/md.0000000000046892
12 Insights on
- Reduced Low-Density Lipoprotein Level
- High evidence
- Clinical
low-density lipoprotein cholesterol (LDL-C) were unaffected.
Effect
Neutral
Effect size
Small
Significant
No

Vitamin D and Reduced Low-Density Lipoprotein Level

Efficacy of pharmacotherapies on pediatric patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and network meta-analysis.

The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.

A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome.