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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Reduced Pain

Doses used in studies

IU/day: 800 (median 800, IQR 800–800) — 1 study

Time to effect

Median: 4.3 weeks · IQR 4.3 weeks–4.3 weeks · Range 4.3 weeks–4.3 weeks — Reported in 1 of 2 studies

2 of 2 papers

Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial.
- 2023-12-18
- RCT · n = 128
- Medicina (Kaunas, Lithuania) 59(12)
- - Dalila Scaturro
  - Fabio Vitagliani
  - Sofia Tomasello
  - Cristiano Sconza
  - Stefano Respizzi
  - Giulia Letizia Mauro
- PubMed: 38138300
- DOI: 10.3390/medicina59122197
2 Insights on
- Reduced Pain
- High evidence
- Large Human Trial
- Clinical
At T1, the Combo group showed statistically superior results compared to the other groups for pain (p < 0.05). At T2, the Combo group showed statistically superior results compared to the other groups only for pain (p < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
800 IU/day
Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights.
- 2024-01-25
- Review
- Nutrients 16(3)
- - Silvia Salvatore
  - Mariagrazia Carlino
  - Simona Sestito
  - Daniela Concolino
  - Massimo Agosti
  - Licia Pensabene
- PubMed: 38337634
- DOI: 10.3390/nu16030349
5 Insights on
- Reduced Pain
- Moderate evidence
- Rigorous Journal
- Clinical
a significant reduction in pain was reported in ... one study on ... vitamin D supplementation
Effect
Beneficial
Effect size
Small
Significant
Yes