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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Reduced Triglyceride Levels

Research synthesisLow evidenceSmall effect4 studies · 2 beneficial · 2 neutral · 0 harmful

Across 4 meta-analyses, 2 reported beneficial small-sized effects of vitamin D supplementation on reducing triglyceride levels, while 2 found neutral results. The beneficial effects were observed in clinical populations (patients with diabetes/prediabetes and metabolic-associated fatty liver disease), but no consistent dose or duration emerged across studies. The overall evidence suggests a small potential benefit, but findings are not uniform.

  • Studied populations: patients with diabetes and prediabetes; patients with metabolic-associated fatty liver disease

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Effects were neutral in a general pediatric population with overweight/obesity, suggesting benefit may be limited to specific clinical subgroups.

Generated May 13, 2026
4 of 4 papers
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