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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D3 and Reduced LDL Cholesterol

Doses used in studies

IU/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 10 weeks · IQR 9 weeks–11 weeks · Range 8 weeks–2.8 months — Reported in 2 of 2 studies

2 of 2 papers

The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.
- 2017-07-25
- RCT · n = 30
- Endocrine research 43(1)
- - Khadijeh Nasri
  - Sedighe Akrami
  - Maryam Rahimi
  - Mohsen Taghizadeh
  - Masoud Behfar
  - Mohammad Reza Mazandaranian
  - Abbas Kheiry
  - Mohammad Reza Memarzadeh
  - Zatollah Asemi
- PubMed: 28742409
- DOI: 10.1080/07435800.2017.1346661
6 Insights on
- Reduced LDL Cholesterol
- High evidence
- Clinical
very low-density lipoprotein (VLDL) cholesterol levels (-1.5 ± 4.7 vs. +1.4 ± 5.3 mg/dL, p = 0.03)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
1000 IU/day
Effects of different vitamin D supplements on body fat distribution and glucolipid metabolism in patients with obesity-associated metabolic syndrome: A meta-analysis.
- 2026-02-20
- Meta-Analysis
- Medicine 105(8)
- - Qin Huang
  - Jidong Zhan
  - Yuan Gui
  - Ming Ma
  - E Li
- PubMed: 41731803
- DOI: 10.1097/md.0000000000047436
4 Insights on
- Reduced LDL Cholesterol
- High evidence
- Clinical
and lowered LDL (MD -0.30 and -0.25 mmol/L)
Effect
Beneficial
Effect size
Moderate
Significant
Yes