Vitamin D3 and Reduced Migraine Frequency

• Oral preventive medications for migraine in adults aged 18-65: a network meta-analysis.

  • 2025-09-04
  • Systematic Review · n = 612
  • Frontiers in pharmacology 16
  • • Jianping Wu
    • Jun Wu
    • Jian Zhang
    • Bingbing Liu
    • Xinyuan Song
    • Yuanjie Wu
    • Fanian Tian
    • Yanbing Ding
    • Ping Wang

  • PubMed: 40978493
  • DOI: 10.3389/fphar.2025.1620887

  1 Insight on

  • Reduced Migraine Frequency

  • High evidence
  • Clinical

  Memantine, melatonin, and vitamin D3 also showed potential preventive effects.

  Effect

  Beneficial

  Effect size

  Small