Vitamin D3 and Reduced Serum Sclerostin Level

• Effect of Vitamin D3, Omega-3 Fatty Acids, and Exercise on Serum Sclerostin Levels and Bone Turnover Markers.

  • 2024-12-09
  • RCT · n = 1,848
  • The Journal of clinical endocrinology and metabolism 110(9)
  • • Elena Tsourdi
    • Stephanie Gängler
    • Melanie Kistler-Fischbacher
    • Martina Rauner
    • Bess Dawson-Hughes
    • E John Orav
    • Li-Tang Tsai
    • Wei Lang
    • John A Kanis
    • Robert Theiler
    • Andreas Egli
    • Heike A Bischoff-Ferrari
    • Lorenz C Hofbauer

  • PubMed: 39657964
  • DOI: 10.1210/clinem/dgae859

  3 Insights on

  • Reduced Serum Sclerostin Level

  • High evidence
  • Large Human Trial
  • Elderly

  Vitamin D3 and omega-3s supplementation alone did not change sclerostin levels significantly

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  2000 IU/day