Across 3 studies, all reported beneficial effects of vitamin E on reducing inflammation, with effect sizes ranging from small to large (mixed). The median study duration was 84 days (12 weeks), though only one study reported duration. The most studied dose was 335 mg/day in a single RCT, and populations included clinical groups such as gastrointestinal surgery patients, older women with sarcopenia, and adults with NAFLD/NASH. The evidence shows moderate consistency for a beneficial effect, but the magnitude varies considerably.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Effect sizes vary widely (small to large), indicating inconsistency in the magnitude of benefit. Only one study reported a specific dose (335 mg/day) and duration (84 days), limiting generalizability.
Using vitamin E and silicone in wound dressings decreased surgical site infection, postoperative pain, inflammation and hospital stay in one trial
IL-6 was lower in the AS group than in the PLA group (P < .001, d = 1.16)
improves histological parameters such as steatosis and inflammation