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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin E and Reduced Inflammation

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of vitamin E on reducing inflammation, with effect sizes ranging from small to large. The median study duration was 84 days (12 weeks), suggesting effects typically observed at 8-12 weeks. The most studied population was clinical adults (e.g., post-surgery, sarcopenic women, NAFLD patients).

  • Effective dose range: 335 mg/d
  • Studied populations: adults undergoing gastrointestinal surgery, older women with sarcopenia, adults with NAFLD/NASH

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).

Generated Jun 11, 2026
Doses used in studies
  • mg/day: 335 (median 335, IQR 335–335) — 1 study
Time to effect
Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 3 studies
3 of 3 papers
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