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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin E and Reduced Malondialdehyde

Doses used in studies

IU/day: 800 (median 800, IQR 800–800) — 1 study
mg/day: 335 (median 335, IQR 335–335) — 1 study

Time to effect

Median: 4.4 months · IQR 3.6 months–5.3 months · Range 2.8 months–6.1 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
Group 2 has substantial improvement in various metabolic parameters and health-related quality of life with accepted safety profile parameters.
from: New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E:

2 of 2 papers

New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.
- 2025-08
- RCT · n = 45
- Clinical therapeutics 47(8)
- - Amr Y Zakaria
  - Rehab Badawi
  - Hasnaa Osama
  - Mona A Abdelrahman
  - Asmaa M El-Kalaawy
- PubMed: 40480879
- DOI: 10.1016/j.clinthera.2025.05.006
13 Insights on
- Reduced Malondialdehyde
- High evidence
- Clinical
both groups reported significant reductions in mean values of ... 27.43% (P = 0.001), respectively
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1200 mg twice daily
Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A randomized, double-blind, placebo-controlled trial.
- 2025-08-22
- RCT
- Medicine 104(34)
- - Xu Liu
  - Bo Chen
  - Yutian Jin
  - Feiyan Zhong
  - Yunjuan Zhang
  - Yu Li
  - Yun Zhang
  - Runhong Cui
  - Bing Wu
  - Cui Li
  - Sheng Xu
  - Xiaohong Chen
- PubMed: 40859523
- DOI: 10.1097/md.0000000000043976
15 Insights on
- Reduced Malondialdehyde
- High evidence
- Clinical
reduced malondialdehyde (P < .001, d = 1.65)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
335 mg/d