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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin K2 and Increased Bone Mineral Density

Doses used in studies

µg/day: 360 (median 360, IQR 360–360) — 1 study

Time to effect

Median: 6 months · IQR 6 months–6 months · Range 6 months–6 months — Reported in 1 of 2 studies

2 of 2 papersPopulation:

Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2.
- 2020-10-17
- RCT · n = 68
- European journal of nutrition 60(3)
- - Jonas W Bartstra
  - Fieke Draaisma
  - Sabine R Zwakenberg
  - Nikolas Lessmann
  - Jelmer M Wolterink
  - Yvonne T van der Schouw
  - Pim A de Jong
  - Joline W J Beulens
- PubMed: 33068157
- DOI: 10.1007/s00394-020-02412-z
2 Insights on
- Increased Bone Mineral Density
- High evidence
- Rigorous Journal
- Clinical
Six months vitamin K supplementation did not ... slow BMD decline (β [95% CI]: - 2.06 [- 11.26; 7.30] Hounsfield units for all vertebrae) when compared to placebo.
Effect
Neutral
Effect size
Small
Significant
No
Dose
360 µg/day
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.
- 2022-08-11
- Meta-Analysis · n = 425
- Frontiers in public health 10
- - Ming-Ling Ma
  - Zi-Jian Ma
  - Yi-Lang He
  - Hao Sun
  - Bin Yang
  - Bin-Jia Ruan
  - Wan-da Zhan
  - Shi-Xuan Li
  - Hui Dong
  - Yong-Xiang Wang
- PubMed: 36033779
- DOI: 10.3389/fpubh.2022.979649
2 Insights on
- Increased Bone Mineral Density
- High evidence
- Elderly
The overall effect test of 10 studies showed a significant improvement in lumbar spine BMD (BMD LS) (P = 0.006) with VK2.
Effect
Beneficial
Effect size
Small
Significant
Yes