Almond and Reduced C-Reactive Protein Levels

Research synthesisLow evidenceSmall effect3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 meta-analyses, almond intake showed no statistically significant effect on C-reactive protein (CRP) levels, with all studies reporting neutral small-sized effects. Evidence is limited to clinical populations including patients with type 2 diabetes, but doses and study durations were not consistently reported. No beneficial or harmful effects were observed.

Studied populations: clinical populations, including patients with type 2 diabetes

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jul 9, 2026

3 of 3 papersPopulation:

The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis.
- 2022-11-04
- Meta-Analysis · n = 1,750
- Phytotherapy research : PTR 36(12)
- - Mojgan Morvaridzadeh
  - Mostafa Qorbani
  - Zahra Shokati Eshkiki
  - M Dulce Estêvão
  - Negar Mohammadi Ganjaroudi
  - Omid Toupchian
  - Shima Abdollahi
  - Ana Beatriz Pizarro
  - Ahmed Abu-Zaid
  - Joshua R Zadro
  - Javad Heshmati
  - Somayeh Ziaei
- PubMed: 36331011
- DOI: 10.1002/ptr.7622
24 Insights on
- Reduced C-Reactive Protein Levels
- High evidence
- Clinical
The effects of almond intake on C-reactive protein (CRP) were not statistically significant
Effect
Neutral
Effect size
Small
Significant
No
A systematic review and meta-analysis of almond effect on C-reactive protein and interleukin-6 in adults.
- 2023-03
- Meta-Analysis
- Complementary therapies in medicine 72
- - Mitra Hariri
  - Bahareh Amirkalali
  - Hamid Reza Baradaran
  - Ali Gholami
- PubMed: 36535459
- DOI: 10.1016/j.ctim.2022.102911
2 Insights on
- Reduced C-Reactive Protein Levels
- High evidence
The overall estimate indicated that the almond consumption had no significant effect on serum CRP level (weighted mean difference (WMD) = -0.28 mg/l, 95 % confidence interval (CI): -0.81, 0.25; p = 0.29).
Effect
Neutral
Effect size
Small
Significant
No
Effects of almond on cardiometabolic outcomes in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.
- 2022-04-20
- Meta-Analysis
- Phytotherapy research : PTR 36(5)
- - Seyedeh Parisa Moosavian
  - Mehran Rahimlou
  - Mahnaz Rezaei Kelishadi
  - Sajjad Moradi
  - Cyrus Jalili
- PubMed: 35443097
- DOI: 10.1002/ptr.7365
13 Insights on
- Reduced C-Reactive Protein Levels
- High evidence
- Clinical
the effect of almond on ... CRP was not significant compared with the control group.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified

Almond and Reduced C-Reactive Protein Levels

The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis.

A systematic review and meta-analysis of almond effect on C-reactive protein and interleukin-6 in adults.

Effects of almond on cardiometabolic outcomes in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.