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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Bovine Colostrum and Reduced Interleukin-6 Levels

Doses used in studies

g/day: 38–60 (median 49, IQR 43.5–54.5) — 2 studies

Time to effect

Median: 6 weeks · IQR 5 weeks–7 weeks · Range 4 weeks–8 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

A multicenter double-blind, placebo-controlled randomized trial to evaluate the safety and efficacy of bovine colostrum in the treatment of severe alcoholic hepatitis (SAH).
- 2023-08-11
- Meta-Analysis · n = 174
- Trials 24(1)
- - S S Sidhu
  - A Dusseja
  - Shalimar
  - S Nijhawan
  - D Kapoor
  - O Goyal
  - H Kishore
- PubMed: 37568158
- DOI: 10.1186/s13063-023-07505-8
8 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Clinical
change in endotoxin and cytokines (alpha TNF, IL6, and IL8) levels
Effect
Neutral
Effect size
Small
Significant
No
Dose
20 g thrice in a day for 4 weeks
Bovine colostrum supplementation in rugby.
- 2025-07-10
- RCT
- European journal of applied physiology 126(1)
- - Eliran Mizelman
  - Keely A Shaw
  - Mojtaba Kaviani
  - Eric Brenna
  - Deborah Haines
  - Philip D Chilibeck
- PubMed: 40640599
- DOI: 10.1007/s00421-025-05900-4
10 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Athletes
No significant changes were observed for ... salivary immune and inflammatory markers (IgA, CRP, IL-6, IL-1β) (p > 0.05)
Effect
Neutral
Effect size
Small
Significant
No
Dose
38 g/day