Research synthesisModerate evidenceMixed effect size5 studies · 5 beneficial · 0 neutral · 0 harmful
Across all 5 studies, every one reported beneficial effects of Cissus quadrangularis on reduced body weight, with 5 out of 5 reaching statistical significance. Effect sizes ranged from small to large, with the largest and highest-quality RCT showing a large effect (~5–6% body weight reduction over 112 days at 300 mg/day). The median study duration was 84 days, indicating effects are typically observed at 12 weeks or more. The most-studied population is overweight or obese adults.
- Effective dose range: 300 mg/day
- Studied populations: overweight and obese adults
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 5 studies) — conclusions should be considered preliminary. Effect sizes varied substantially across studies (small to large), and one study combined Cissus with other herbs, making the independent effect unclear. The highest-quality trial used a specific extract dose of 300 mg/day for 112 days, but dosing was not consistently reported across all studies.
Generated Jul 11, 2026