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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Cissus quadrangularis and Reduced Body Weight

Research synthesisLow evidenceLarge effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Cissus quadrangularis on reduced body weight, with predominantly large effect sizes. Two studies show significant weight loss (e.g., -5.2% to -5.8% over 112 days in a 2025 RCT of 248 overweight/obese adults). Effects typically observed at 8-16 weeks; the most-studied population is overweight or obese adults.

  • Effective dose range: 300 mg/day
  • Studied populations: overweight or obese adults

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The 2025 RCT used a specific extract; form details were not reported across studies, so applicability to other Cissus extracts is uncertain.

Generated May 15, 2026
Doses used in studies
  • mg/day: 300 (median 300, IQR 300–300) — 1 study
Time to effect
Median: 3.3 months · IQR 3 months–3.5 months · Range 2.8 months–3.7 months — Reported in 2 of 3 studies
Safety in these studies
3 of 3 papers
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