Research synthesisHigh evidenceMixed effect size5 studies · 5 beneficial · 0 neutral · 0 harmful
All 5 studies report beneficial effects of Cissus quadrangularis on reduced body weight, with 5 of 5 reaching statistical significance. Effect sizes range from small to large, with RCTs showing moderate-to-large reductions (e.g., -5.2% to -5.8% body weight at 300 mg/day over 16 weeks). The most common dose was 300 mg/day, and the median study duration was 84 days (12 weeks), suggesting effects typically observed at 8–12+ weeks. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed).
- Effective dose range: 300 mg/day
- Studied populations: overweight or obese adults (BMI 25–34.9 kg/m²)
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 5 studies) — conclusions should be considered preliminary. One systematic review included studies where Cissus quadrangularis was combined with other herbs, making it difficult to isolate the independent effect of Cissus alone. Doses were not consistently reported across all studies.
Generated Jun 11, 2026