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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Cissus quadrangularis and Reduced Waist Circumference

Time to effect

Median: 9 weeks · IQR 8.5 weeks–9.5 weeks · Range 8 weeks–10 weeks — Reported in 2 of 2 studies

2 of 2 papers

The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study.
- 2008
- RCT · n = 24
- Lipids in health and disease 7(1)
- - Julius E Oben
  - Judith L Ngondi
  - Claudia N Momo
  - Gabriel A Agbor
  - Caroline S Makamto Sobgui
- PubMed: 18377661
- DOI: 10.1186/1476-511x-7-12
6 Insights on
- Reduced Waist Circumference
- High evidence
- Clinical
the Cissus quadrangularis-only group showed significant reductions on all variables compared to the placebo group
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
twice daily before meals (exact dose not specified in abstract)
Cissus Quadrangularis enhances UCP1 mRNA, indicative of white adipocyte browning and decreases central obesity in humans in a randomized trial.
- 2021-01-21
- RCT
- Scientific reports 11(1)
- - Saimai Chatree
  - Chantacha Sitticharoon
  - Pailin Maikaew
  - Kitchaya Pongwattanapakin
  - Issarawan Keadkraichaiwat
  - Malika Churintaraphan
  - Chanakarn Sripong
  - Rungnapa Sririwichitchai
  - Sompol Tapechum
- PubMed: 33479386
- DOI: 10.1038/s41598-021-81606-9
3 Insights on
- Reduced Waist Circumference
- High evidence
- Rigorous Journal
- Clinical
CQ treatment in obese humans significantly decreased waist circumference at week 4 and week 8 when compared with the baseline values (p < 0.05 all)
Effect
Beneficial
Effect size
Small
Significant
Yes