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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Fish Oil and Reduced Depression Symptoms

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 1 study

1 of 1 paper

The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial.
- 2025-07
- RCT · n = 57
- Journal of affective disorders 380
- - Murat Açik
  - Funda Pınar Çakiroğlu
  - Atilla Tekin
  - Aslı Egeli
- PubMed: 40118278
- DOI: 10.1016/j.jad.2025.03.097
10 Insights on
- Reduced Depression Symptoms
- High evidence
- Clinical
The mean HDRS scores decreased significantly in both the krill-oil (8.5 ± 1.2) and fish-oil groups (10.0 ± 1.2) compared to the placebo (p < 0.001)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
600 mg EPA + DHA daily