flaxseed and Reduced Diastolic Blood Pressure

Research synthesisModerate evidenceModerate effect4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects (small to moderate reductions) on diastolic blood pressure, while 1 high-quality meta-analysis found a neutral effect. Predominant effect size among beneficial studies is moderate. Studies primarily focused on clinical populations with metabolic or cardiovascular conditions.

Studied populations: people with type 2 diabetes, metabolic diseases, cardiovascular risk factors, or hypertension

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. One high-quality meta-analysis observed a neutral effect, conflicting with other beneficial findings; this inconsistency warrants caution. Doses were not consistently reported across studies, limiting dose-response interpretation.

Generated Jul 10, 2026

Doses used in studies

Glycinate · mg/day: 420 (median 420, IQR 420–420) — 1 study

4 of 4 papers

The effect of flaxseed supplementation on anthropometric indices, blood pressure, and lipid profile in diabetic patients: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
- 2025-05
- Meta-Analysis · n = 1,136
- Diabetes & metabolic syndrome 19(5)
- - Vali Musazadeh
  - Shokufeh Nezamoleslami
  - Amir Hossein Faghfouri
  - Farzad Shidfar
  - Naheed Aryaeian
- PubMed: 40499336
- DOI: 10.1016/j.dsx.2025.103241
9 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
- Clinical
diastolic blood pressure (SMD: 0.74; 95% CI: 1.51, 0.03, p = 0.060)
Effect
Neutral
Effect size
Small
Significant
No
Can flaxseed supplementation alleviate blood pressure in patients with metabolic diseases? Evaluating the strength of evidence using a meta-analysis and GRADE approach.
- 2025-06-12
- Review · n = 209
- Journal of diabetes and metabolic disorders 24(2)
- - Vali Musazadeh
  - Niloofar Hamidi
  - Mahsa Mahmoudinezhad
  - Ali Jafari
  - Farzad Shidfar
- PubMed: 40520241
- DOI: 10.1007/s40200-025-01656-y
2 Insights on
- Reduced Diastolic Blood Pressure
- High evidence
- Clinical
Meta-analysis of 18 trials ... revealed significant reductions in both systolic ... and diastolic blood pressure (WMD = -2.50 mmHg; 95% CI: -3.88, -1.12, p < 0.001)
Effect
Beneficial
Effect size
Small
Significant
Yes
Efficacy of flaxseed in reducing blood pressure among patients with cardiovascular risk factors: A systematic review and meta-analysis of parallel randomized controlled trials.
- 2025-03-18
- Review
- Journal of cardiovascular and thoracic research 17(1)
- - Refli Hasan
  - Raed Obaid Saleh
  - Rana H Raheema
  - Hanen Mahmod Hulail
  - Irfan Ahmad
  - Deepak Nathiya
  - Parjinder Kaur
- PubMed: 40365516
- DOI: 10.34172/jcvtr.025.33280
2 Insights on
- Reduced Diastolic Blood Pressure
- Low evidence
- Clinical
and diastolic BP (DBP) (WMD: -3.09 mmHg, 95% CI: -4.37 to -1.81, P≤0.001; I²=91.2%)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
not specified in abstract
Flaxseed Lowers Blood Pressure in Hypertensive Subjects: A Meta-Analysis of Randomized Controlled Trials.
- 2024-10-29
- Review
- Clinical nutrition research 13(4)
- - Ezatollah Fazeli Moghadam
  - Leili Khaghani
  - Parivash Shekarchizadeh-Esfahani
- PubMed: 39526211
- DOI: 10.7762/cnr.2024.13.4.295
2 Insights on
- Reduced Diastolic Blood Pressure
- Low evidence
- Clinical
diastolic BP (WMD, -4.87 mmHg; 95% CI, -8.37 to -1.37; p = 0.006)
Effect
Beneficial
Effect size
Moderate
Significant
Yes

flaxseed and Reduced Diastolic Blood Pressure

The effect of flaxseed supplementation on anthropometric indices, blood pressure, and lipid profile in diabetic patients: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

Can flaxseed supplementation alleviate blood pressure in patients with metabolic diseases? Evaluating the strength of evidence using a meta-analysis and GRADE approach.

Efficacy of flaxseed in reducing blood pressure among patients with cardiovascular risk factors: A systematic review and meta-analysis of parallel randomized controlled trials.

Flaxseed Lowers Blood Pressure in Hypertensive Subjects: A Meta-Analysis of Randomized Controlled Trials.