Red Clover and Reduced Vasomotor Symptom

Time to effect

Median: 12.2 months · IQR 12.2 months–12.2 months · Range 12.2 months–12.2 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityNo significant difference
Secondary measures indicated that both botanicals were safe as administered.
from: Safety and efficacy of black cohosh and red clover for the management of vasomotor symptom
Overall tolerabilityReported
Safety monitoring indicated that chemically and biologically standardized extracts of black cohosh and red clover were safe during daily administration for 12 months.
from: Safety and efficacy of black cohosh and red clover for the management of vasomotor symptom

1 of 1 paper

Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.

2009-11
RCT · n = 89
Menopause (New York, N.Y.) 16(6)
- Stacie E Geller
- Lee P Shulman
- Richard B van Breemen
- Suzanne Banuvar
- Ying Zhou
- Geena Epstein
- Samad Hedayat
- Dejan Nikolic
- Elizabeth C Krause
- Colleen E Piersen
- Judy L Bolton
- Guido F Pauli
- Norman R Farnsworth

PubMed: 19609225
DOI: 10.1097/gme.0b013e3181ace49b

4 Insights on

Reduced Vasomotor Symptom

High evidence
Highly Cited
Clinical

Reductions in number of vasomotor symptoms after a 12-month intervention were as follows: ... red clover (57%), placebo (63%)... with only CEE/MPA differing significantly from placebo. Black cohosh and red clover did not significantly reduce the frequency of vasomotor symptoms as compared with placebo.

Effect: Neutral
Effect size: Small
Significant: No
Dose: standardized extract, dose not specified