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Evidence-Based Supplement Research
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red yeast rice and Reduced Apolipoprotein B Levels

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, 2 of which reached statistical significance, red yeast rice shows consistently beneficial moderate-to-large effects on reducing apolipoprotein B (apoB) levels. The median study duration is 56 days, indicating effects typically observed at 8 weeks. The most commonly studied doses include low-dose red yeast rice (200 mg/day) and monacolin K up to 10 mg/day, primarily in clinical populations with mild dyslipidemia or hyperlipidemia.

  • Effective dose range: 200 mg/day red yeast rice or up to 10 mg/day monacolin K
  • Studied populations: adults with mild dyslipidemia or hyperlipidemia

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). One review combined doses ranging from 200 to 4800 mg daily, which introduces heterogeneity that may affect interpretation.

Generated Jul 10, 2026
Doses used in studies
  • mg/day: 10–4,800 (median 200, IQR 105–2,500) — 3 studies
Time to effect
Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 3 studies
Safety in these studies
3 of 3 papers
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