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Evidence-Based Supplement Research

Evidence-Based Supplement Research

red yeast rice and Reduced LDL Cholesterol

Doses used in studies

mg/day: 2–10 (median 6, IQR 2–10) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
3 of the included studies reported adverse side effects after treatment with monacolin K.
from: Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of

2 of 2 papersPopulation:

Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of clinical trials.
- 2024-05
- Systematic Review · n = 769
- Semergen 50(4)
- - E Liasi
  - M Kantilafti
  - E Hadjimbei
  - S Chrysostomou
- PubMed: 38310834
- DOI: 10.1016/j.semerg.2023.102156
2 Insights on
- Reduced LDL Cholesterol
- High evidence
- Adults
All studies indicated a beneficial effect of monacolin supplementation on LDL and total cholesterol levels (p<0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
2-10 mg/day
Impact of red yeast rice supplementation on lipid profile: a systematic review and meta-analysis of randomized-controlled trials.
- 2022-10-25
- Meta-Analysis
- Expert review of clinical pharmacology 16(1)
- - Parisa Rahmani
  - Ebru Melekoglu
  - Sogand Tavakoli
  - Nasser Malekpour Alamdari
  - Pejman Rohani
  - Mohammad Hassan Sohouli
- PubMed: 36259545
- DOI: 10.1080/17512433.2023.2138342
4 Insights on
- Reduced LDL Cholesterol
- High evidence
- Clinical
significant effectiveness in lowering LDL-C (WMD: -28.94 mg/dl, 95% CI: -32.90, -24.99, P < 0.001)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
less than 1200 mg