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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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saccharomyces boulardii and Reduced Duration of Diarrhea

Research synthesisVery low evidenceSmall effect4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies on saccharomyces boulardii for reducing diarrhea duration, 3 reported beneficial effects (predominantly small to moderate in size). The evidence is strongest in children with acute diarrhea, but the only meta-analysis showed a neutral effect with a non-significant mean difference. No consistent dose range or study duration was reported.

  • Studied populations: Children with acute non-bloody diarrhea, children under 5 with acute gastroenteritis, infants under 2 years with acute infectious gastroenteritis

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive (3 of 4 studies beneficial) — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The single meta-analysis found no significant reduction in diarrhea duration, conflicting with the positive small trials.

Generated Jul 20, 2026
Safety in these studies
4 of 4 papers
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