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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Watercress and Reduced Interleukin-6 Levels

Doses used in studies

g/day: 100 (median 100, IQR 100–100) — 1 study
g/kg/day: 85–750 (median 417.5, IQR 85–750) — 1 study

Time to effect

Median: 3 weeks · IQR 3 weeks–3 weeks · Range 3 weeks–3 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
WC had a strong safety profile.
from: Evaluating the Anti-Oxidant and Anti-Inflammatory Properties of Watercress Supplementation

2 of 2 papersPopulation:

Evaluating the Anti-Oxidant and Anti-Inflammatory Properties of Watercress Supplementation at Short-Term Follow-Up: A Systematic Review of Randomized Controlled Trials.
- 2025-06
- Review · n = 302
- Food science & nutrition 13(6)
- - Jimmy Wen
  - Muhammad Karabala
  - Zohaer Muttalib
  - Burhaan Syed
  - Ramy Khalil
  - Daniel Razick
  - Adam Razick
  - David Pai
- PubMed: 40488189
- DOI: 10.1002/fsn3.70407
18 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Clinical
Inflammatory markers included ... one study reporting on interleukin-6 ...
Effect
Beneficial
Effect size
Small
Dose
85 g/day to 750 mg/kg/day
The acute effect of incorporating lettuce or watercress into a moderately high-fat meal on postprandial lipid, glycemic response, and plasma inflammatory cytokines in healthy young men: a randomized crossover trial.
- 2021-07-15
- RCT
- Lipids in health and disease 20(1)
- - Sahar Shokraei
  - Nafiseh Khandouzi
  - Zahra Sina
  - Javad Nasrollahzadeh
- PubMed: 34261489
- DOI: 10.1186/s12944-021-01487-9
8 Insights on
- Reduced Interleukin-6 Levels
- High evidence
- Adults
Moreover, the levels of plasma IL-6 and TNF-α did not differ among the meals.
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 g