Best Supplements for Reduced All-Cause Mortality
Ranked by research evidence. Compare 23 supplements across 31 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across 3 studies, all reported beneficial effects on reducing all-cause mortality, with effect sizes ranging from small to moderate (predominantly moderate). The largest meta-analysis (N=564,748) found a 13% risk reduction (HR=0.87, 95% CI: 0.85–0.90) for ever or weekly chili pepper consumption. Evidence is consistent but based solely on observational data and two meta-analyses with high heterogeneity.
- Low evidence3 studies
Across 3 studies, 1 reported beneficial moderate-sized effects, while 2 reported neutral small effects. The evidence is preliminary due to the small number of studies and mixed results. Most studies did not find a statistically significant benefit.
Product matchViva Naturals — Vitamin D3 with Organic Liquid Coconut Oil125 mcg · $15.16 · ★5.0 (208)
- ModerateChili PepperAcross 3 studies, all reported beneficial effects on reducing all-cause mortality, with effect sizes ranging from small to moderate (predominantly moderate). The largest meta-analysis (N=564,748) found a 13% risk reduction (HR=0.87, 95% CI: 0.85–0.90) for ever or weekly chili pepper consumption. Evidence is consistent but based solely on observational data and two meta-analyses with high heterogeneity.3 beneficial3 studies
- LowVitamin DAcross 3 studies, 1 reported beneficial moderate-sized effects, while 2 reported neutral small effects. The evidence is preliminary due to the small number of studies and mixed results. Most studies did not find a statistically significant benefit.1 beneficial2 neutral3 studies