Best Supplements for Reduced Bleeding on Probing (BOP)
Ranked by research evidence. Compare 29 supplements across 35 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence5 studies
Across 5 studies, 3 reported beneficial effects on reducing bleeding on probing (BOP) and 2 found no benefit over placebo. Effect sizes among beneficial studies ranged from small to large (mixed), with two RCTs showing moderate-to-large significant reductions and one observational study showing a small effect. The predominant population studied was adults with periodontitis (stages III/IV, grades B/C), including those with diabetes or betel quid chewing habits. Only 2 studies reported duration (median 101 days, about 14 weeks), but no consistent dose or form emerged across trials.
- ModerateLactobacillus reuteriAcross 5 studies, 3 reported beneficial effects on reducing bleeding on probing (BOP) and 2 found no benefit over placebo. Effect sizes among beneficial studies ranged from small to large (mixed), with two RCTs showing moderate-to-large significant reductions and one observational study showing a small effect. The predominant population studied was adults with periodontitis (stages III/IV, grades B/C), including those with diabetes or betel quid chewing habits. Only 2 studies reported duration (median 101 days, about 14 weeks), but no consistent dose or form emerged across trials.3 beneficial2 neutral5 studies