Best Supplements for Reduced Bleeding on Probing (BOP)
Ranked by research evidence. Compare 19 supplements across 22 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence4 studies
Across 4 studies, 3 reported beneficial effects of Lactobacillus reuteri on reducing bleeding on probing (BOP), with effect sizes ranging from small to moderate, while 1 study found no benefit. The predominant effect size is mixed (small to moderate). The most-studied dose was lozenges taken twice daily, though CFU counts were inconsistently reported. Effects were observed primarily in patients with periodontitis, and the median study duration across the 1 study reporting duration was 21 days, which is relatively short for periodontal outcomes.
Dose: 2 lozenges/day (specific CFU not consistently reported)
19 supplements
- LowLactobacillus reuteriAcross 4 studies, 3 reported beneficial effects of Lactobacillus reuteri on reducing bleeding on probing (BOP), with effect sizes ranging from small to moderate, while 1 study found no benefit. The predominant effect size is mixed (small to moderate). The most-studied dose was lozenges taken twice daily, though CFU counts were inconsistently reported. Effects were observed primarily in patients with periodontitis, and the median study duration across the 1 study reporting duration was 21 days, which is relatively short for periodontal outcomes. · Dose: 2 lozenges/day (specific CFU not consistently reported)3 beneficial1 neutral4 studies