Best Supplements for Reduced High-Density Lipoprotein Cholesterol Level
Ranked by research evidence. Compare 9 supplements across 11 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, the evidence on flaxseed supplementation for reducing high-density lipoprotein cholesterol (HDL-C) is mixed: no studies found a beneficial effect, 2 reported neutral effects, and 1 reported a small harmful effect (statistically significant reduction in HDL-C). The only significant finding suggests flaxseed may slightly lower HDL-C in postmenopausal women, but the predominant effect size is small and the overall direction is neutral to harmful. No consistent dose or form data were available, and study durations were not consistently reported.
9 supplements
- LowflaxseedAcross 3 studies, the evidence on flaxseed supplementation for reducing high-density lipoprotein cholesterol (HDL-C) is mixed: no studies found a beneficial effect, 2 reported neutral effects, and 1 reported a small harmful effect (statistically significant reduction in HDL-C). The only significant finding suggests flaxseed may slightly lower HDL-C in postmenopausal women, but the predominant effect size is small and the overall direction is neutral to harmful. No consistent dose or form data were available, and study durations were not consistently reported.2 neutral1 harmful3 studies