Best Supplements for Reduced High-Density Lipoprotein Cholesterol Level
Ranked by research evidence. Compare 9 supplements across 11 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 meta-analyses, flaxseed supplementation shows no evidence of reducing HDL cholesterol. Two studies reported neutral effects (small effect size), while one study found a small harmful effect (statistically significant decrease) in postmenopausal women. The predominant effect size is small, and no consistent dose or form data were reported.
9 supplements
- LowflaxseedAcross 3 meta-analyses, flaxseed supplementation shows no evidence of reducing HDL cholesterol. Two studies reported neutral effects (small effect size), while one study found a small harmful effect (statistically significant decrease) in postmenopausal women. The predominant effect size is small, and no consistent dose or form data were reported.2 neutral1 harmful3 studies