Best Supplements for Reduced Probing Depth
Ranked by research evidence. Compare 13 supplements across 19 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, 2 reported beneficial small-sized effects of propolis on probing depth, while the highest-scoring meta-analysis found a neutral effect. Study durations and doses were not consistently reported.
- Low evidence3 studies
Across 3 RCTs, 1 reported a beneficial large effect on probing depth reduction, while 2 reported neutral effects (small reductions not statistically significant vs. placebo). The predominant effect is neutral, with small effect sizes in the neutral studies. The only beneficial study used 1×10⁹ CFU/day for 8 weeks in patients with periodontitis or gingivitis; the two neutral studies lasted 6 months in diabetic patients with periodontitis. Evidence is limited and inconclusive.
- LowPropolisAcross 3 studies, 2 reported beneficial small-sized effects of propolis on probing depth, while the highest-scoring meta-analysis found a neutral effect. Study durations and doses were not consistently reported.2 beneficial1 neutral3 studies
- LowLactobacillus reuteriAcross 3 RCTs, 1 reported a beneficial large effect on probing depth reduction, while 2 reported neutral effects (small reductions not statistically significant vs. placebo). The predominant effect is neutral, with small effect sizes in the neutral studies. The only beneficial study used 1×10⁹ CFU/day for 8 weeks in patients with periodontitis or gingivitis; the two neutral studies lasted 6 months in diabetic patients with periodontitis. Evidence is limited and inconclusive.1 beneficial2 neutral3 studies