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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Berberine and Increased HDL Cholesterol Levels

Doses used in studies

mg/day: 1,200 (median 1,200, IQR 1,200–1,200) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityNo significant difference
Regarding safety, no significant difference was observed between berberine and placebo.
from: Efficacy and safety of berberine on the components of metabolic syndrome: a systematic rev

2 of 2 papersPopulation:

The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.
- 2025-02-25
- RCT
- European journal of nutrition 64(2)
- - Asieh Mansour
  - Sayed Mahmoud Sajjadi-Jazi
  - Hadis Gerami
  - Atie Sadat Khorasanian
  - Behnam Moalemzadeh
  - Sara Karimi
  - Nima Mohamadi Afrakoti
  - Vahid Mofid
  - Mohammad Reza Mohajeri-Tehrani
  - Azita Hekmatdoost
- PubMed: 39998703
- DOI: 10.1007/s00394-025-03618-9
10 Insights on
- Increased HDL Cholesterol Levels
- High evidence
- Rigorous Journal
- Clinical
no difference was observed in the levels of ... high density lipoprotein cholesterol (HDL-C)
Effect
Neutral
Effect size
Small
Significant
No
Dose
600 mg/day
Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials.
- 2025-07-16
- Systematic Review
- Frontiers in pharmacology 16
- - Dangzhen Liu
  - Haiyan Zhao
  - Yiwen Zhang
  - Jingqing Hu
  - Hong Xu
- PubMed: 40740996
- DOI: 10.3389/fphar.2025.1572197
10 Insights on
- Increased HDL Cholesterol Levels
- High evidence
has no significant effect on high-density lipoprotein cholesterol (HDL-C)
Effect
Neutral
Effect size
Small
Significant
No
Dose
not stated in the abstract