Berberine and Reduced 5-Hydroxytryptamine Level

• Gut microbiota-mediated berberine metabolism ameliorates cholestatic liver disease by suppressing 5-hydroxytryptamine production.

  • 2025-10-14
  • RCT
  • Clinical and molecular hepatology 32(1)
  • • Dianji Tu
    • Cheng Lu
    • Junfeng Guo
    • Qiao Chen
    • Xin Li
    • Yingjie Wang
    • Lulu Cheng
    • Hongfei Jiang
    • Jincheng Jian
    • Yusong Ge
    • Zhanjie Hou
    • Xiaojie Feng
    • Yunxuan Feng
    • Jianchun Zhou
    • Yuanyuan Lei
    • Hua Diao
    • Lei Ran
    • Yuanyuan Zhou
    • Zhengguo Xu
    • Jiyin Zhou
    • Bo Tang
    • Shiming Yang

  • PubMed: 41087029
  • DOI: 10.3350/cmh.2025.0577

  2 Insights on

  • Reduced 5-Hydroxytryptamine Level

  • High evidence
  • Clinical

  A clinical study validated that BBR improved blood biochemical indicators in patients with CLD and decreased 5-HT levels.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes