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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Berberine and Reduced High-Density Lipoprotein Cholesterol Level

Doses used in studies

mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
No serious adverse event was reported.
from: Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Contr

1 of 1 paper

Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial.
- 2021-07-26
- RCT · n = 84
- Nutrients 13(8)
- - Jie V Zhao
  - Wai-Fung Yeung
  - Yap-Hang Chan
  - Dana Vackova
  - June Y Y Leung
  - Dennis K M Ip
  - Jiaxi Zhao
  - Wai-Kwan Ho
  - Hung-Fat Tse
  - Catherine Mary Schooling
- PubMed: 34444711
- DOI: 10.3390/nu13082550
9 Insights on
- Reduced High-Density Lipoprotein Cholesterol Level
- High evidence
- Rigorous Journal
- Clinical
larger reductions in...high-density lipoprotein cholesterol (-0.07 mmol/L, 95% CI -0.13 to -0.01)
Effect
Harmful
Effect size
Small
Significant
Yes
Dose
500 mg orally, twice a day