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Evidence-Based Supplement Research
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Black Cumin and Reduced Alanine Aminotransferase Level

Research synthesisLow evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies (2 meta-analyses, 1 RCT), only 1 large meta-analysis reported a small beneficial effect of black cumin supplementation on reducing alanine aminotransferase (ALT) levels, while 2 studies found no significant effect. The overall effect direction is neutral, with small effect sizes across all studies.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The one beneficial finding came from a large meta-analysis, but two other meta-analyses/RCTs failed to replicate the benefit, and study durations were short (median 19 days), which may not be adequate to observe ALT changes.

Generated Jul 10, 2026
Doses used in studies
  • mL/every 8 hours: 2.5 (median 2.5, IQR 2.5–2.5) — 1 study
  • mg/day: 200–4,600 (median 2,400, IQR 200–4,600) — 1 study
Time to effect
Median: 2.6 weeks · IQR 13 days–3.5 weeks · Range 7 days–4.3 weeks — Reported in 2 of 3 studies
Safety in these studies
3 of 3 papers
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