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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Black Cumin and Reduced Alkaline Phosphatase Level

Doses used in studies

mL/every 8 hours: 2.5 (median 2.5, IQR 2.5–2.5) — 1 study
mg/day: 200–4,600 (median 2,400, IQR 200–4,600) — 1 study

Time to effect

Median: 2.6 weeks · IQR 13 days–3.5 weeks · Range 7 days–4.3 weeks — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
There was no side effect.
from: Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarth

2 of 2 papersPopulation:

Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.
- 2025-09
- Meta-Analysis · n = 5,026
- Pharmacological research 219
- - Ali Jafari
  - Helia Mardani
  - Amir Hossein Faghfouri
  - Zahra Mirzaei Fashtali
  - Mohtaram Hashemi
  - Matin Abdollahi Yousefabady
  - Reihane Javid
  - Sahar Golabi
  - Bahareh Arghavan
  - Vali Musazadeh
  - Mahshid Naghashpour
- PubMed: 40714301
- DOI: 10.1016/j.phrs.2025.107882
35 Insights on
- Reduced Alkaline Phosphatase Level
- High evidence
N. sativa supplementation significantly improved ... alkaline phosphatase (ALP)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
200 to 4600 mg/day
Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial.
- 2022-11
- RCT · n = 58
- Complementary therapies in clinical practice 49
- - Hasan Fallah Huseini
  - Reza Mohtashami
  - Elaheh Sadeghzadeh
  - Soraya Shadmanfar
  - Fataneh Hashem-Dabaghian
  - Saeed Kianbakht
- PubMed: 36150238
- DOI: 10.1016/j.ctcp.2022.101666
10 Insights on
- Reduced Alkaline Phosphatase Level
- High evidence
- Clinical
The NS oil had no significant effect on the other variables.
Effect
Neutral
Effect size
Small
Significant
No
Dose
2.5 mL every 8 hours