Black Cumin and Reduced Creatinine Level

Across the 3 available studies, 1 reported a small beneficial effect of Black Cumin supplementation on reducing creatinine levels, while 2 studies found neutral (no significant) effects. The beneficial finding came from a large meta-analysis (82 RCTs, 5026 participants) testing doses from 200 to 4600 mg/day over a median study duration of 19 days. Evidence primarily derives from general and clinical populations, but the overall effect direction is mixed, with the predominant effect size being small.

• Effective dose range: 200 to 4600 mg/day
• Studied populations: General adult population (meta-analysis) and clinical populations (type 2 diabetes patients, knee osteoarthritis patients)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Only 1 of 3 studies reported a statistically significant effect, and effect sizes were small across all studies. The beneficial meta-analysis is very recent (2025) and large, but the neutral meta-analysis and RCT suggest inconsistency, especially in clinical populations. The median study duration is very short (19 days), so longer-term effects on creatinine are unknown.