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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Black Cumin and Reduced Vascular Cell Adhesion Molecule-1 Level

Research synthesisModerate evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small-sized effects on reducing VCAM-1 levels, with a median study duration of 56 days (8 weeks). The most-studied doses were 1–2 g/day of Nigella sativa, primarily in populations with cardiovascular disease risk factors or coronary artery disease.

  • Effective dose range: 1–2 g/day
  • Studied populations: individuals with cardiovascular disease risk factors or coronary artery disease

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One of the three studies (a small RCT with 50 participants) found no significant effect, which may be due to limited statistical power. The meta-analysis provides the strongest support, but individual study heterogeneity exists.

Generated Jul 13, 2026
Doses used in studies
  • mg/day: 200–4,600 (median 1,700, IQR 400–3,700) — 2 studies
  • g/day: 2 (median 2, IQR 2–2) — 1 study
Time to effect
Median: 8 weeks · IQR 4.5 weeks–8.3 weeks · Range 7 days–8.6 weeks — Reported in 3 of 3 studies
3 of 3 papers
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