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Evidence-Based Supplement Research
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Black Cumin and Reduced Vascular Cell Adhesion Molecule-1 Level

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial small effects of black cumin (Nigella sativa) supplementation on reducing VCAM-1 levels, while 1 found no significant change. The strongest evidence comes from a comprehensive meta-analysis of 82 RCTs (n=5026) and an RCT in coronary artery disease patients, using doses typically between 1–2 g/day. The median study duration was 56 days, suggesting effects may require several weeks of supplementation.

  • Effective dose range: 1–2 g/day
  • Studied populations: people with cardiovascular disease risk factors or coronary artery disease

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One RCT in 50 participants with CVD risk factors found no significant effect, contrasting with positive findings from a larger meta-analysis and another RCT. The meta-analysis reported a short duration (7 days), which may reflect data extraction issues; however, the median duration across studies was 56 days.

Generated Jun 13, 2026
Doses used in studies
  • mg/day: 200–4,600 (median 1,700, IQR 400–3,700) — 2 studies
  • g/day: 2 (median 2, IQR 2–2) — 1 study
Time to effect
Median: 8 weeks · IQR 4.5 weeks–8.3 weeks · Range 7 days–8.6 weeks — Reported in 3 of 3 studies
3 of 3 papers
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