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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Black Cumin and Reduced Waist Circumference

Doses used in studies

mg/day: 200–4,600 (median 1,700, IQR 400–3,700) — 2 studies

Time to effect

Median: 8.5 weeks · IQR 4.8 weeks–2.9 months · Range 7 days–3.7 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.
- 2025-09
- Meta-Analysis · n = 5,026
- Pharmacological research 219
- - Ali Jafari
  - Helia Mardani
  - Amir Hossein Faghfouri
  - Zahra Mirzaei Fashtali
  - Mohtaram Hashemi
  - Matin Abdollahi Yousefabady
  - Reihane Javid
  - Sahar Golabi
  - Bahareh Arghavan
  - Vali Musazadeh
  - Mahshid Naghashpour
- PubMed: 40714301
- DOI: 10.1016/j.phrs.2025.107882
35 Insights on
- Reduced Waist Circumference
- High evidence
N. sativa supplementation significantly improved ... waist circumference (WC)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
200 to 4600 mg/day
The possible short-term of Nigella sativa - L in the management of adolescent polycystic ovarian syndrome: results of a randomized controlled trial.
- 2024-07-12
- RCT · n = 103
- Journal of ovarian research 17(1)
- - Azamsadat Mahmoudian
  - Akram Ashouri
  - Roghaieh Rahmani Bilandi
  - Fatemeh Mohammadzadeh
  - Sareh Dashti
  - Narjes Bahri
- PubMed: 38997723
- DOI: 10.1186/s13048-024-01460-x
11 Insights on
- Reduced Waist Circumference
- High evidence
- Large Human Trial
- Clinical
Anthropometric ... were evaluated but no significant changes are reported in the abstract; thus assumed not significant.
Effect
Neutral
Effect size
Small
Significant
No
Dose
1000 mg/day