Research synthesisLow evidenceMixed effect size3 studies · 1 beneficial · 2 neutral · 0 harmful
Across 3 studies, 1 reported a moderate beneficial effect on LDL reduction, while 2 reported neutral effects. The beneficial finding came from a meta-analysis of 821 participants (MD -0.64 mmol/L, 95% CI -0.77 to -0.52), but two subsequent meta-analyses and RCTs found no significant effect, with small effect sizes and wide confidence intervals. The median study duration was 90 days, but evidence is limited and inconsistent.
- Studied populations: Mixed populations including healthy adults, those at high risk of CVD, and individuals with hypercholesterolemia.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The only positive study is from 2013, while two more recent meta-analyses and an RCT found no significant effect, suggesting potential publication bias or a diminishing effect over time.
Generated Jul 16, 2026