Effectiveness of black tea versus placebo in subjects with hypercholesterolemia: A PRISMA systematic review and meta-analysis.
- 2019-05
- Diabetes & metabolic syndrome 13(3)
- Felipe Araya-Quintanilla
- Héctor Gutiérrez-Espinoza
- Valeria Moyano-Gálvez
- María Jesús Muñoz-Yánez
- Leonardo Pavez
- Katherine García
- PubMed: 31235165
- DOI: 10.1016/j.dsx.2019.05.019
Study Design
- Type
- Meta-Analysis
- Population
- subjects older than 18 years of age with hypercholesterolemia
- Methods
- Systematic review with meta-analysis of randomized clinical trials (RCTs)
Aim
To determine if the black tea is more effective in serum lipid profile that placebo in subjects with hypercholesterolemia.Design
Systematic review with meta-analysis of randomized clinical trials (RCTs).Data sources
The databases Medline, Central, Embase, Lilacs, Cinahl, SPORTDiscus, and Web of Science were searched from inception up to January 2019.Eligibility criteria for selecting studies
RCTs that compared black tea versus placebo, that included serum lipid profile outcomes in subjects older than 18 years of age with hypercholesterolemia.Results
Seven RCTs met the eligibility criteria, and for the quantitative synthesis, six studies were included. Mean difference for total cholesterol was 1.67 mg/dl 95% CI = -5.47 to 8.80 (p = 0.65), mean difference 0.28 mg/dl, 95% CI = -3.89 to 4.45 (p = 0.90) for triglycerides, mean difference 3.21 mg/dl, 95% CI = -11.02 to 4.60 (p = 0.42) for low density lipoprotein-cholesterol, mean difference 0.38 mg/dl, 95% CI = -1.12 to 1.87 (p = 0.62) for high density lipoprotein-cholesterol.Conclusion
In the short term, no significant differences were found in lipid serum profile comparing black tea consumption with placebo.Research Insights
mean difference 0.38 mg/dl, 95% CI = -1.12 to 1.87 (p = 0.62) for high density lipoprotein-cholesterol
- Effect
- Neutral
- Effect size
- Small
Mean difference for total cholesterol was 1.67 mg/dl 95% CI = -5.47 to 8.80 (p = 0.65)
- Effect
- Neutral
- Effect size
- Small
mean difference 3.21 mg/dl, 95% CI = -11.02 to 4.60 (p = 0.42) for low density lipoprotein-cholesterol
- Effect
- Neutral
- Effect size
- Small
mean difference 0.28 mg/dl, 95% CI = -3.89 to 4.45 (p = 0.90) for triglycerides
- Effect
- Neutral
- Effect size
- Small