Passion Flower and Reduced Heart Rate

Research synthesisLow evidenceSmall effect3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 studies, all reported neutral, small-sized effects of passion flower on reduced heart rate, with no statistically significant findings. The most-studied dose range was 260-500 mg in adults undergoing dental extraction. Effects were predominantly neutral and small, indicating no clear evidence for a heart rate-lowering benefit.

Effective dose range: 260-500 mg
Studied populations: adults undergoing third molar extraction

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. All studies were conducted in dental extraction settings, which may limit generalizability to other populations.

Generated Jul 17, 2026

Doses used in studies

mg/day: 260–500 (median 260, IQR 260–380) — 3 studies

3 of 3 papersPopulation:

Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial.
- 2020-09-19
- RCT · n = 200
- Clinical oral investigations 25(3)
- - Rafael Soares da Cunha
  - Klinger Souza Amorim
  - Anne Caroline Gercina
  - Allan Carlos Araújo de Oliveira
  - Liciane Dos Santos Menezes
  - Francisco Carlos Groppo
  - Liane Maciel Almeida Souza
- PubMed: 32951121
- DOI: 10.1007/s00784-020-03468-1
4 Insights on
- Reduced Heart Rate
- High evidence
- Large Human Trial
- Adults
Considering each procedure independently, no significant differences (p > 0.05) in BP, HR, and SpO2 were observed among the protocols.
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 mg
Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.
- 2017-01-01
- RCT
- Medicina oral, patologia oral y cirugia bucal 22(1)
- - L-P Dantas
  - A de Oliveira-Ribeiro
  - L-M de Almeida-Souza
  - F-C Groppo
- PubMed: 27918731
- DOI: 10.4317/medoral.21140
5 Insights on
- Reduced Heart Rate
- High evidence
- Clinical
Considering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2.
Effect
Neutral
Effect size
Small
Significant
No
Dose
260 mg
Effects of Passiflora incarnata on salivary biomarkers and anxiety in patients undergoing third molar extraction surgery.
- 2025-12-11
- RCT · n = 10
- Scientific reports 15(1)
- - Tiburtino J Lima Neto
  - Natália Pereira Ribeiro
  - Mileni Buzo Souza
  - Rayara Nogueira Freitas
  - Sachin Karande
  - Carlos Fernando Mourão
  - Antonio Hernandes Chaves-Neto
  - Leonardo P Faverani
- PubMed: 41381570
- DOI: 10.1038/s41598-025-27468-x
6 Insights on
- Reduced Heart Rate
- High evidence
- Rigorous Journal
- Clinical
No significant differences were observed between groups regarding anxiety scores or most physiological measures (p > 0.05).
Effect
Neutral
Effect size
Small
Significant
No

Passion Flower and Reduced Heart Rate

Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial.

Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.

Effects of Passiflora incarnata on salivary biomarkers and anxiety in patients undergoing third molar extraction surgery.