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Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.

  • 2017-01-01
  • Medicina oral, patologia oral y cirugia bucal 22(1)
    • L-P Dantas
    • A de Oliveira-Ribeiro
    • L-M de Almeida-Souza
    • F-C Groppo

Study Design

Type
Randomized Controlled Trial (RCT)
Population
40 adults undergoing bilateral mandibular third molar extraction
Methods
Randomized, controlled, double-blind, crossover clinical trial; Passiflora incarnata 260 mg or midazolam 15 mg orally 30 min before surgery
Blinding
Double-blind
Funding
Unclear

Background

Anxiety symptoms are frequently observed in dental patients, whether they are undergoing simple or more invasive procedures such as surgery. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction.

Material and methods

Forty volunteers underwent bilateral extraction of their mandibular third molars in a randomized, controlled, double-blind, crossover clinical trial. Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. The anxiety level of participants was evaluated by questionnaires and measurement of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2).

Results

Considering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2. Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols. With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.

Conclusions

Passiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars.

Research Insights

  • Passion Flower→Improved Oxygen Saturation

    Considering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2.

    Effect
    Neutral
    Effect size
    Small
    Dose
    260 mg
  • Passion Flower→Reduced Amnesia

    With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.

    Effect
    Neutral
    Effect size
    Small
    Dose
    260 mg
  • Passion Flower→Reduced Anxiety

    Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. ... Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    260 mg
  • Passion Flower→Reduced Blood Pressure

    Considering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2.

    Effect
    Neutral
    Effect size
    Small
    Dose
    260 mg
  • Passion Flower→Reduced Heart Rate

    Considering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2.

    Effect
    Neutral
    Effect size
    Small
    Dose
    260 mg
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