Research synthesisModerate evidenceSmall effect10 studies · 8 beneficial · 2 neutral · 0 harmful
Across 10 studies, 8 reported beneficial effects of passion flower on anxiety, with the predominant effect size being small. The evidence is strongest for acute anxiety in clinical settings (e.g., prior to dental or surgical procedures), with doses around 260–500 mg of Passiflora incarnata used. Effect sizes were predominantly small, though a few studies reported moderate effects.
- Effective dose range: 260-500 mg of Passiflora incarnata (single dose, typically 30-60 minutes before a procedure)
- Studied populations: adults undergoing dental or surgical procedures (e.g., third molar extraction, elective surgery)
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies focus on acute, situational anxiety rather than chronic anxiety disorders, and many lack consistent reporting on form and duration, limiting generalizability.
Generated Jun 15, 2026