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Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.

  • 2024-05-14
  • Oral and maxillofacial surgery 28(3)
    • Amalia Celsy Abregu Velasquez
    • Mayumi Tsuji
    • Lidiana Dos Santos Cordeiro
    • Maria Fernanda Pivetta Petinati
    • Nelson Luis Barbosa Rebellato
    • Aline Monise Sebastiani
    • Delson João da Costa
    • Rafaela Scariot

Study Design

Type
Randomized Controlled Trial (RCT)
Population
Fifty-four patients undergoing extraction of two unilateral third molars
Methods
Randomized, triple-blinded clinical trial; patients allocated to Valeriana officinalis L., Passiflora incarnata L., or placebo
Blinding
Double-blind
Funding
Unclear

Objective

This study evaluated the efficacy of Valeriana officinalis L. and Passiflora incarnata L. to control anxiety, surgical discomfort, and changes in vital signs of patients undergoing extraction of two unilateral third molars.

Materials and methods

This study is a randomized, triple-blinded clinical trial. Fifty-four patients were allocated into three groups (Valeriana officinalis L., Passiflora incarnata L., and placebo). Anxiety levels were assessed using the State-Trace Anxiety Inventory (STAI) index, surgical discomfort using the QCirDental, and through the measurement of vital signs. The surgical times evaluated were before (T0), during (T1), and after surgery (T2).

Results

There was evidence that both Valeriana officinalis L. and Passiflora incarnata L., reduced STAY-S scores between T0 and T2 (p < .05), unlike placebo (p = .129). There was no change in surgical discomfort in all groups over time, and vital signs presented variable results.

Conclusion

Phytotherapy drugs showed a reduction in anxiety state compared to the placebo group during third molar extraction procedure.  CLINICAL TRIAL REGISTRATION: klRBR-6kcxvrc, March 10, 2022.

Research Insights

  • Passion Flower→Reduced Anxiety

    both Valeriana officinalis L. and Passiflora incarnata L., reduced STAY-S scores between T0 and T2 (p < .05), unlike placebo (p = .129)

    Effect
    Beneficial
    Effect size
    Moderate
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