Clinical effectiveness and safety of total glucosides of paeony as an immunomodulator in patients with refractory oral lichen planus: A multicenter, pragmatic, randomized controlled trial.
- 2026-02
- RCT · n = 448
- Phytomedicine : international journal of phytotherapy and phytopharmacology 151
- Yiwen Deng
- Leilei Zhou
- Na Li
- Fan Huang
- Guanhuan Du
- Yufeng Wang
- Jian Meng
- Shijie Chen
- Xiufeng Wei
- Wenmei Wang
- Guoyao Tang
- PubMed: 41539096
- DOI: 10.1016/j.phymed.2026.157770
- High evidence
- Large Human Trial
- Clinical
TGP group demonstrated significantly faster achievement of CR and higher CR rates compared to controls (53.9% vs. 34.4%; hazard ratio [HR] 2.07, 95% confidence interval [CI] 1.52-2.82; p < 0.0001)
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- 0.6 g three times daily