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Evidence-Based Supplement Research
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Quercetin and Reduced C-Reactive Protein Levels

Research synthesisLow evidenceMixed effect size3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, 2 reported neutral effects (small non-significant changes) and 1 reported a beneficial moderate effect. The overall evidence is mixed, with the only beneficial finding coming from a low-quality review (n=34), while a higher-quality RCT and a larger meta-analysis found no significant changes in CRP. Doses ranged from 500 to 3000 mg daily, but no clear dose range emerged; the median study duration in the single study reporting it was 90 days.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The beneficial effect was observed in a review with limited sample size, while a randomized controlled trial (n=33) and a larger meta-analysis (n=544) found no significant change. Many of the included studies did not reach statistical significance (2 of 3 neutral) — the effect may be smaller than the single beneficial finding suggests.

Generated Jul 18, 2026
Doses used in studies
  • mg/day: 500–3,000 (median 1,125, IQR 500–2,375) — 2 studies
Time to effect
Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 3 studies
3 of 3 papers
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